HCID 67497844, compound → HCID 67498800, compound

Participants

Reaction Steps

To a solution of 3-(4-biphenylyl)-2-[N-(5-dibenzylaminopentyl)-N-methylamino]-4-methoxycarbonylmethyl-3,4-dihydroquinazoline (19) (362 mg, 0.556 mmol) in methanol (20 ml) was added 10% Pd(C) (883 mg), and the reaction mixture was stirred under hydrogen atmosphere for 24 hours. After the reaction was completed, the resulting reaction mixture was filtered with celite, extracted with dichloromethane three times and washed with a saline solution. The combined organic phase was dried with anhydrous magnesium sulfate and distilled under reduced pressure. The resulting residue was subjected to silica gel column chromatography (eluent: dichloromethane:methanol:ammonia water=100:9:1) to give the target compound as a yellow liquid (110 mg, 42%).

Provenance & Evidence