Ammonium Chloride → HCID 66769369, compound

HRID 1919568Notes

Reaction equation

HRID 1919568 reaction equation
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7]#[N:8])[N:6]=1.C[O-].[Na+].[Cl-].[NH4+:13]>CO>[ClH:1].[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([NH2:13])=[NH:8])[N:6]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 10942334Sodium MethoxideHCID 451216532-Chloro-1,3-thiazole-4-carbonitrile

Product 1

HCID 66769369HCID 66769369, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 mmol 2-chloro-4-cyanothiazole was dissolved in 10 ml anhydrous methanol, and 10 mmol sodium methoxide was added. Upon complete reaction of the starting materials, 20 mmol ammonium chloride was added, to carry out reaction in closed state for 12 hr. The reaction product was filtered to remove inorganic salt, and then the resultant filtrate was concentrated to obtain 2-chloro-4-thiazolformamidine hydrochloride.

Workup

  1. additionwas added
  2. customreaction in closed state for 12 hr
  3. filtrationThe reaction product was filtered
  4. customto remove inorganic salt
  5. concentrationthe resultant filtrate was concentrated

Sources & evidence

ORD record
ord-4e03d73f121542eea25dfef6ebb1b23e
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

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