Ethyl Acetoacetate → HCID 24810557, compound

Participants

Reaction Steps

2 mmol 2-Acetylaminothiazol-5-formamidine acetate, 2 mmol 2-chloro-4-fluorobenzaldehyde, 2 mmol ethyl acetoacetate and 2.2 mmol sodium acetate were reacted under reflux in 10 ml anhydrous ethanol for 20 hr, concentrated, and then ethyl acetate and water were added to separate the layers. The ethyl acetate layer was dried over anhydrous sodium sulfate, and separated by a column chromatography to obtain 0.32 g of a yellowish solid with mp>250° C.; 1H-NMR (400 MHz, DMSO-d6) δ 1.0-1.05 (3H, m); 2.14 (3H, s); 2.43 (3H, s); 2.59 (3H, s); 3.89-3.94 (2H, m); 5.89 (1H, s); 7.14-7.39 (3H, m); 8.11 (1H, s); 9.43 (1H, s); 12.22 (1H, br); MS (EI) 436.0 (M+).

Provenance & Evidence