Ammonium Chloride → HCID 67499792, compound

HRID 1919578Notes

Reaction equation

HRID 1919578 reaction equation
[Cl:1][C:2]1[S:3][C:4]([C:7]#[N:8])=[CH:5][N:6]=1.C[O-].[Na+].[Cl-].[NH4+:13]>CO>[ClH:1].[Cl:1][C:2]1[S:3][C:4]([C:7]([NH2:13])=[NH:8])=[CH:5][N:6]=1

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 14852222-Chlorothiazole-5-carbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 67499792HCID 67499792, compoundYield 159.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.43 g 2-chloro-5-cyanothiazole was dissolved in 8 ml anhydrous methanol, and 0.16 g sodium methoxide was added, to carry out the reaction with stirring for 15 min; and then, 0.48 g ammonium chloride was added, to further carry out reaction in closed state for 24 hr; finally, the reaction product was filtered to remove insoluble matters, and the resultant filtrate was concentrated, and recrystallized from isopropanol to obtain 0.47 g a yellow crystalline solid (yield 79%).

Workup

  1. customthe reaction
  2. customreaction in closed state for 24 hr
  3. filtrationfinally, the reaction product was filtered
  4. customto remove insoluble matters
  5. concentrationthe resultant filtrate was concentrated
  6. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-ff57307809f6432e8131ab067438eb03
Source dataset
uspto-grants-2012_05
Patent number
US08168642B2

Reaction notes

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