Sodium bis(trimethylsilyl)amide → HCID 178510029, compound

Participants

Reaction Conditions

Reaction Steps

4 amino-3-chlorobenzonitrile was charged in a vial. NaHMDS (1 M solution in THF, 0.2 ml) was added and the solution stirred at 80° C. for 5 min. A suspension of 5-chloro-7-(4H-1,2,4-triazol-3-yl)benzo[c][2,6]naphthyridine (30 mg) in NMP (0.5 ml) was added and the solution stirred at 80° C. for 30 min. The mixture was cooled down, a few drops of HCl and NMP (1 ml) were added and mixture was purified by preparative HPLC to provide 4-(7-(4H-1,2,4-triazol-3-yl)benzo[c][2,6]naphthyridin-5-ylamino)-3-chlorobenzonitrile (25 mg).

Provenance & Evidence