HCID 67498983, compound → HCID 67498962, compound

Participants

Reaction Steps

A solution of trans-N-Boc-2-methyl-6-(ethenyl propionyl)piperidine (2.0 g, 6.70 mmol) in 3 mL of ethanol was shaken under 58 psi of H2 pressure over 0.65 g Pd/C catalyst overnight, and then the mixture was filtered through Celite and concentrated to give 1.8 g (90%) of the product which was homogeneous by TLC analysis. 1H NMR (250 MHz) δ 4.16-4.08 (q, 2H), 3.93-3.83 (m, 2H), 2.36-2.28 (t, 2H), 2.04-1.08 (m, 20H); 13C NMR (62.7 MHz) 155.4 (s), 79.1 (s), 60.3 (s), δ 1.0 (s), 47.2 (s), 31.9 (s), 29.6 (s), 28.5 (s), 26.9 (s), 25.8 (s), 24.2 (s), 20.5 (s), 14.2 (s) ppm.

Provenance & Evidence