HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Isocyanato-2-(trifluoromethyl)benzonitrile → 4-[2,5-Dioxo-4-(4-hydroxyphenyl)-4-methylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Isocyanato-2-(trifluoromethyl)benzonitrile | HCID 11063739 | — |
| Reactant | Methyl 2-amino-2-(4-hydroxyphenyl)propionate | HCID 59235258 | — |
| Product | 4-[2,5-Dioxo-4-(4-hydroxyphenyl)-4-methylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile | HCID 59235288 | — |
Reaction Steps
This product is prepared as in Example 5, starting from 10.71 g of methyl 2-amino-2-(4-hydroxyphenyl)propionate using 4-cyano-3-trifluoromethylphenyl isocyanate. 16.83 g of product are obtained (Yd=82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168667B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d8e1feb1bd8a4ccda0a1678f9a3ff8b1 |
| Source note | uspto-grants-2012_05 |