HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → HCID 57951168, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | Ethyl pyruvate | HCID 12041 | — |
| Reactant | 3-(Trifluoromethoxy)benzaldehyde | HCID 605139 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 57951168 | HCID 57951168 | 60% |
Reaction Steps
Stir 3-(trifluoromethoxy)benzaldehyde (15.0 g, 78.6 mmol), 4-fluoroaniline (22.4 mL, 236 mmol) and ethyl pyruvate (8.65 mL, 78.6 mmol) in glacial acetic acid (60 mL) at ambient temperature for 72 hours. Filter the precipitate and wash with a 3:1 heptane/MTBE mixture. Dry under vacuum to afford the titled compound (20.9 g, 60%) as an off-white powder: MS (m/z): 445 (M−1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168659B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9d226e2e1cc04f6cb5f5e07d24772d8e |
| Source note | uspto-grants-2012_05 |