HuagongsheHuagongshe Chemistry Print Report · For research reference only
(7-Nitro-1H-benzimidazol-1-yl)acetic acid → N-[(1S)-1-(4-hydroxyphenyl)ethyl]-2-(7-nitro-1H-benzimidazol-1-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (7-Nitro-1H-benzimidazol-1-yl)acetic acid | HCID 11379027 | — |
| Reactant | (S)-4-(1-Aminoethyl)phenol | HCID 41097924 | — |
| Product | N-[(1S)-1-(4-hydroxyphenyl)ethyl]-2-(7-nitro-1H-benzimidazol-1-yl)acetamide | HCID 67500286 | — |
Reaction Steps
The title compound was synthesised according to the general method of synthesis of target compounds (see below) from (7-nitro-1H-benzimidazol-1-yl)acetic acid and 4-[(1S)-1-aminoethyl]phenol. 1H NMR (400 MHz, DMSO-d6) δ ppm 9.26 (s, 1 H) 8.55 (d, J=8.03 Hz, 1 H) 8.40 (s, 1 H) 8.10 (d, J=8.03 Hz, 1 H) 7.98 (d, J=7.53 Hz, 1 H) 7.39 (t, J=8.03 Hz, 1 H) 7.05-7.15 (m, 2 H) 6.64-6.75 (m, 2 H) 5.19 (s, 2 H) 4.71-4.83 (m, 1 H) 1.32 (d, J=6.78 Hz, 3 H). MS (ESI) m/z: 341 [M+H]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-192c73525af94014a5c4e0f3db820010 |
| Source note | uspto-grants-2012_05 |