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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1919821Generated: October 28, 2026

2-Fluoroethanol → 1-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamine

https://huagongshe.com/reaction/1919821

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-FluoroethanolHCID 9737—
Reactant6-Chloro-3-pyridinecarbonitrileHCID 5152094—
Reactant3-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)-HCID 58629100—
Product1-[6-(2-Fluoroethoxy)pyridin-3-yl]ethanamineHCID 58629095—

Reaction Steps

The title compound was synthesised according to the 2-step procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloronicotinonitrile and 2-fluoroethanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08168668B2
Source datasetuspto-grants-2012_05
ORD IDord-7dbdb655881948e3a0d3d77d4a0ca428
Source noteuspto-grants-2012_05