2,2,3,3-Tetrafluoro-1-propanol → HCID 81899701, compound

HRID 1919823Notes

Reaction equation

HRID 1919823 reaction equation
[F:1][C:2]([F:15])(F)[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1.ClC1C=CC(C#N)=CN=1.[F:25][C:26]([F:32])(C(F)F)CO>>[F:1][C:2]([F:15])([CH:26]([F:32])[F:25])[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 64412,2,3,3-Tetrafluoro-1-propanolHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 586291003-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)-

Product 1

HCID 81899701HCID 81899701, compound

Procedure

The title compound was synthesised according to the 2-step procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine starting from 6-chloronicotinonitrile and 2,2,3,3-tetrafluoropropan-1-ol.

Sources & evidence

ORD record
ord-696ff8089f264b6799a2f43392a9e8f4
Source dataset
uspto-grants-2012_05
Patent number
US08168668B2

Reaction notes

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