HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,2,2-Trifluoroethoxy)benzonitrile → 1-(4-(2,2,2-Trifluoroethoxy)phenyl)ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,2,2-Trifluoroethoxy)benzonitrile | HCID 10954594 | — |
| Reactant | 3-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)- | HCID 58629100 | — |
| Product | 1-(4-(2,2,2-Trifluoroethoxy)phenyl)ethan-1-amine | HCID 16782340 | — |
Reaction Steps
The title compound was synthesised according to the procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine, step B, starting from 4-(2,2,2-trifluoroethoxy)benzonitrile. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.28-7.34 (m, 2 H) 6.94-7.00 (m, 2 H) 4.70 (q, J=8.78 Hz, 2 H) 3.95 (q, J=6.53 Hz, 1 H) 1.21 (d, J=6.78 Hz, 3 H). MS (ESI) m/z: 220 [M+H]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1c0fd56d89774018bff4bd7dc3b4c189 |
| Source note | uspto-grants-2012_05 |