反应详情

The title compound was synthesized according to the procedure described for the synthesis of [1-(6-tert-butylpyridin-3-yl)ethyl]amines starting from 6-tert-butyl-4-methylnicotinonitrile (intermediate 24) (250 mg, 1.43 mmol), MeMgBr 1.4 M 75/25 toluene/THF (2.55 ml, 3.58 mmol) and NaBH4 (135 mg, 3.58 mmol). Purified by normal phase chromatography with 15 to 20% MeOH/CH2Cl2. (Yield 55 mg, 20%). 1H NMR (400 MHz, CDCl3) δ ppm 1.34 (s, 9 H) 1.42 (d, J=6.64 Hz, 3 H) 2.35 (s, 3 H) 4.34 (q, J=6.64 Hz, 1 H) 7.07 (s, 1 H) 8.60 (s, 1 H).

1. customPurified by normal phase chromatography with 15 to 20% MeOH/CH2Cl2