Trimethyl orthoformate → HCID 67490749, compound

Participants

Reaction Steps

To a solution of 4-(cyclohexylthio)benzaldehyde (215 mg, 0.976 mmol) in methanol (4 mL) was added trimethylorthoformate (130 μL, 1.19 mmol) and p-toluenesulfonic acid (15 mg, 0.079 mmol), and the resulting solution stirred at room temperature for 72 hours. Sodium methoxide solution (25 wt %, 18 μL) was then added to the solution, and the volatiles removed in vacuo to afford crude cyclohexyl(4-(dimethoxymethyl)phenyl)sulfane (˜265 mg, quantitative yield) which was used directly without further purification.

Provenance & Evidence