HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-{1-[(Acetylamino)methyl]-2-anilino-2-oxoethyl}benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-{1-[(acetylamino)methyl]-2-anilino-2-oxoethyl}benzoate | HCID 57611876 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-{1-[(Acetylamino)methyl]-2-anilino-2-oxoethyl}benzoic acid | HCID 57611950 | — |
Reaction Steps
To a solution of tert-butyl 4-{1-[(acetylamino)methyl]-2-anilino-2-oxoethyl}benzoate (273 mg, 0.71 mmol) in CH2Cl2 (8 mL) was added trifluoroacetic acid (2 mL), and the reaction was stirred at room temperature for 2 h. The solution was evaporated to dryness to yield 4-{1-[(acetylamino)methyl]-2-anilino-2-oxoethyl}benzoic acid as an off-white powder that was carried on without further purification. MS (ESI) calcd [M+H]+ 327.1, found 327.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168658B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6a3e2415de004c7b98f75c430e6f5e13 |
| Source note | uspto-grants-2012_05 |