Trifluoroacetic acid → HCID 24753858, compound

Participants

Reaction Steps

To a solution of the trifluoroacetic acid salt of tert-butyl [2-[(4-{2-anilino-1-[(dimethylamino)methyl]-2-oxoethyl}benzoyl)amino]-4-(3-thienyl)phenyl]carbamate (374 mg, 0.54 mmol) in CH2Cl2 (8 mL) was added trifluoroacetic acid (2 mL), and the reaction was stirred at room temperature for 1 h. Concentration yielded a yellow residue that was purified by reverse phase HPLC (10-70% MeCN/water). The resulting solid was dissolved in CH2Cl2 (with a small amount of MeOH), neutralized with sat. NaHCO3, washed with brine, dried (MgSO4), and evaporated to yield N-[2-amino-5-(3-thienyl)phenyl]-4-{2-anilino-1-[(dimethylamino)methyl]-2-oxoethyl}benzamide as an off-white solid.

Provenance & Evidence