Acetyl chloride → HCID 44159412, compound

HRID 1919926Notes

Reaction equation

HRID 1919926 reaction equation
C[O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[CH:23]=O)[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.[CH:26]1([NH2:29])[CH2:28][CH2:27]1.[C:30](Cl)(=[O:32])[CH3:31]>>[C:30]([N:29]([CH2:23][C:14]1[CH:15]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:18][C:13]=1[C:7]1[C:8]([O:11][CH3:12])=[CH:9][CH:10]=[C:5]([CH2:4][C:3]([OH:25])=[O:2])[CH:6]=1)[CH:26]1[CH2:28][CH2:27]1)(=[O:32])[CH3:31]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 69828CyclopropylamineHCID 86633167(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 44159412HCID 44159412, compound

Procedure

{2′-[(Acetyl-cyclopropyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (Compound 1-12) was prepared following the procedures of Example 1 and using (2′-formyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester, cyclopropylamine, and acetyl chloride.

Sources & evidence

ORD record
ord-71525060ad6345f2a0c2d7a7c7a8c534
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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