Cyclobutanecarbonyl chloride → HCID 44158940, compound

HRID 1919940Notes

Reaction equation

HRID 1919940 reaction equation
C([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)C.[CH:29]1([C:33](Cl)=[O:34])[CH2:32][CH2:31][CH2:30]1>>[CH:29]1([C:33]([N:25]([CH2:24][C:15]2[CH:16]=[C:17]([C:20]([F:22])([F:23])[F:21])[CH:18]=[CH:19][C:14]=2[C:8]2[C:9]([O:12][CH3:13])=[CH:10][CH:11]=[C:6]([CH2:5][C:4]([OH:3])=[O:28])[CH:7]=2)[CH2:26][CH3:27])=[O:34])[CH2:32][CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 78705Cyclobutanecarbonyl chlorideHCID 66604101(2'-Ethylaminomethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 44158940HCID 44158940, compound

Procedure

{2′-[(Cyclobutanecarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (Compound 1-206) was prepared using the procedures of Example 1 and using (2′-ethylaminomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester and cyclobutanecarbonyl chloride.

Sources & evidence

ORD record
ord-9c06a68d7f79415c8356c3b31f4d515c
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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