Pivaloyl chloride → HCID 44159061, compound

HRID 1919941Notes

Reaction equation

HRID 1919941 reaction equation
C([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)C.[CH3:29][C:30]([CH3:35])([CH3:34])[C:31](Cl)=[O:32]>>[CH3:29][C:30]([CH3:35])([CH3:34])[C:31]([N:25]([CH2:24][C:15]1[CH:16]=[C:17]([C:20]([F:21])([F:23])[F:22])[CH:18]=[CH:19][C:14]=1[C:8]1[C:9]([O:12][CH3:13])=[CH:10][CH:11]=[C:6]([CH2:5][C:4]([OH:3])=[O:28])[CH:7]=1)[CH2:26][CH3:27])=[O:32]

Participants

3

Reactant 2

HCID 62493Pivaloyl chlorideHCID 66604101(2'-Ethylaminomethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester

Product 1

HCID 44159061HCID 44159061, compound

Procedure

(2′-{[(2,2-Dimethyl-propionyl)-ethyl-amino]-methyl}-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid (Compound 1-245) was prepared using the procedures of Example 1 and using (2′-ethylaminomethyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid ethyl ester and trimethylacetyl chloride.

Sources & evidence

ORD record
ord-7b676f0ec63e40179415b849afb2f737
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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