Acetyl chloride → HCID 44159410, compound

HRID 1919952Notes

Reaction equation

C[O:2][C:3](=[O:29])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][C:25]([F:28])([F:27])[F:26])[C:8]([F:11])=[CH:9][CH:10]=1.[C:30](Cl)(=[O:32])[CH3:31]>>[C:30]([N:23]([CH2:22][C:13]1[CH:14]=[C:15]([C:18]([F:21])([F:19])[F:20])[CH:16]=[CH:17][C:12]=1[C:7]1[C:8]([F:11])=[CH:9][CH:10]=[C:5]([CH2:4][C:3]([OH:2])=[O:29])[CH:6]=1)[CH2:24][C:25]([F:28])([F:27])[F:26])(=[O:32])[CH3:31]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 86633170{6-Fluoro-2'-[(2,2,2-trifluoro-ethylamino)-methyl]-4'-trifluoromethyl-biphenyl-3-yl}acetic acid methyl ester

Product 1

HCID 44159410HCID 44159410, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6 and Step 7, using the following starting materials: {6-fluoro-2′-[(2,2,2-trifluoro-ethylamino)-methyl]-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid methyl ester and acetyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-089b3f1eb6524af489665adbbe44a53a
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08168678B2

Reaction notes

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