Ethanol → Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

HRID 1919965Notes

Reaction equation

HRID 1919965 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].S(=O)(=O)(O)O.[CH3:18][CH2:19]O>>[CH2:18]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 27696283-Bromo-4-hydroxyphenylacetic acid

Product 1

HCID 18620106Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

Procedure

(3-Bromo-4-hydroxy-phenyl)-acetic acid (5.6 mmol) in EtOH (20 mL) was treated with sulfuric acid (1 mL) and stirred at room temperature over the weekend. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-9da065a587f54e598c3e1c13c579a5ff
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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