Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate → {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-hydroxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

HRID 1919968Notes

Reaction equation

HRID 1919968 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8](Br)[CH:7]=1)[CH3:2].[CH2:15]([O:22][C:23](=[O:47])[N:24]([CH2:45][CH3:46])[CH2:25][C:26]1[CH:31]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:29]=[CH:28][C:27]=1B1OC(C)(C)C(C)(C)O1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[CH:7]=[C:8]([C:27]2[CH:28]=[CH:29][C:30]([C:32]([F:33])([F:34])[F:35])=[CH:31][C:26]=2[CH2:25][N:24]([C:23]([O:22][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:47])[CH2:45][CH3:46])[C:9]([OH:12])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 18620106Ethyl 2-(3-bromo-4-hydroxyphenyl)acetateHCID 66603618(Ethyl)[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethylbenzyl]carbamic acid benzyl ester

Product 1

HCID 66604011{2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-6-hydroxy-4'-trifluoromethyl-biphenyl-3-yl}-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: (3-bromo-4-hydroxy-phenyl)-acetic acid ethyl ester and ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid benzyl ester.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c1e66e53b026486e935d7bf973edffa7
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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