HuagongsheHuagongshe Chemistry Print Report · For research reference only
Clofibric Acid → 2-(4-Chlorophenoxy)-2-methylpropanoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Clofibric Acid | HCID 2797 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Chlorophenoxy)-2-methylpropanoyl chloride | HCID 2781312 | — |
Reaction Steps
2-(4-Chloro-phenoxy)-2-methyl-propionic acid (0.124 g, 0.58 mmol) and triethylamine (0.09 mL, 0.62 mmol) were combined in CH2Cl2 (2 mL) and cooled to 0 C. Oxalyl chloride (0.05 mL, 0.62 mmol) was added, followed by DMF (3 drops), and the mixture was slowly warmed to room temperature and stirred for 2 hours to give the title compound, which was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168678B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d66e8989d1764eeebb57580f40e4d5ca |
| Source note | uspto-grants-2012_05 |