Ethanol → HCID 66604210, compound

HRID 1920000Notes

Reaction equation

HRID 1920000 reaction equation
[CH2:1]([NH:3][CH2:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][C:22]([OH:24])=[O:23])[CH:16]=1)[CH3:2].[CH3:25][CH2:26]O>S(=O)(=O)(O)O>[CH2:25]([O:23][C:22](=[O:24])[CH2:21][C:17]1[CH:16]=[C:15]([C:6]2[CH:7]=[CH:8][C:9]([C:11]([F:13])([F:12])[F:14])=[CH:10][C:5]=2[CH2:4][NH:3][CH2:1][CH3:2])[CH:20]=[CH:19][CH:18]=1)[CH3:26]

Participants

4

Reactant 2

HCID 702EthanolHCID 66603992HCID 66603992, compound

Product 1

HCID 66604210HCID 66604210, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Conditions

Temperature
50 °C

Procedure

To a solution of (2′-ethylaminomethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid (0.34 mmol) in EtOH (7 mL) was added sulfuric acid (3-4 drops), and the reaction was stirred at 50° C. overnight. Once no starting material was seen by analytical LCMS, the mixture was filtered over a pad of Celite and rinsed with EtOH. The filtrate was concentrated to give the title compound.

Workup

  1. filtrationthe mixture was filtered over a pad of Celite
  2. washrinsed with EtOH
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-a7c72bf33be14c399f23413aebe65815
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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