HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → {2'-[(Acetyl-ethyl-amino)-methyl]-4'-fluoro-6-methoxy-biphenyl-3-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | (2'-Ethylaminomethyl-4'-fluoro-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester | HCID 58149135 | — |
| Reactant | {2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4'-fluoro-6-methoxy-biphenyl-3-yl}-acetic acid ethyl ester | HCID 58149210 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | {2'-[(Acetyl-ethyl-amino)-methyl]-4'-fluoro-6-methoxy-biphenyl-3-yl}-acetic acid | HCID 56849341 | — |
Reaction Steps
{2′-[(Acetyl-ethyl-amino)-methyl]-4′-fluoro-6-methoxy-biphenyl-3-yl}-acetic acid (Compound 1-184) was prepared by reacting (2′-ethylaminomethyl-4′-fluoro-6-methoxy-biphenyl-3-yl)-acetic acid ethyl ester and acetyl chloride according to the procedure described in Example 1, Step 6 and then hydrolyzing the ester with aqueous LiOH in THF at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168678B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-f4f5930d5b9a43938602d0ec896c68c6 |
| Source note | uspto-grants-2012_05 |