HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | HCID 59253663 | HCID 59253663 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine | HCID 10686149 | — |
Reaction Conditions
| Temperature | 180 °C |
|---|
Reaction Steps
To 25 mL N-methylpyrrolidone, 5.0 g 2-[(2-methyl-5-nitrophenyl)amino]-4-(3-pyridinyl)pyrimidine-5-carboxylic acid and 0.2 g cupric oxide is added. The mixture is heated to 180° C. for 2 hours, then cooled to 60° C., and 30% aqueous ammonia 1 mL and 50 mL water is added. It is cooled to 25° C., and the precipitate is filtrated, yielding, upon drying, 4.3 g of product with HPLC purity of 97% (A %), which is identified through GC-MS.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168787B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-21dd3cf488504ff0887500333ff43ed5 |
| Source note | uspto-grants-2012_05 |