HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-5-Carboxylic Acid → HCID 67501352, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-5-Carboxylic Acid | HCID 74280 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Azatricyclo[3.3.1.13,7]decane-4-methanamine | HCID 18937847 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 67501352 | HCID 67501352 | — |
Reaction Steps
The product of Example 1B was reacted with indole-5-carboxylic acid, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole and 4-di(methylamino)pyridine in pyridine as described in Example 3 to afford the title compound: 1H NMR (methanol-d4, 500 MHz) δ 1.82-1.89 (m, 2 H), 1.96 (br s, 3 H), 2.22-2.28 (m, 2 H), 2.31 (t, 1 H), 3.31-3.36 (m, 2 H), 3.41-3.47 (m, 2 H), 3.60-3.66 (m, 2 H), 6.54 (dd, J=3.20, 0.76 Hz, 1 H), 7.22-7.28 (m, 1H), 7.32 (d, J=3.05 Hz, 1 H), 7.42 (d, J=8.54 Hz, 1 H), 7.60-7.62 (m, 1 H), 7.64-7.70 (m, 1 H), 8.11 ppm (d, J=1.22 Hz, 1 H); MS (ESI) m/z 310 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168791B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-eecd6444169f4a3d84279ad557a3deb6 |
| Source note | uspto-grants-2012_05 |