HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-5-Carboxylic Acid → HCID 67501352, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-5-Carboxylic Acid | HCID 74280 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Azatricyclo[3.3.1.13,7]decane-4-methanamine | HCID 18937847 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 67501352 | HCID 67501352 | — |
Reaction Steps
The product of Example 2B was reacted with indole-5-carboxylic acid, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole and 4-di(methylamino)pyridine in pyridine as described in Example 3 to afford the title compound: 1H NMR (methanol-d4, 500 MHz) δ 1.91 (br s, 2 H), 1.94-2.01 (m, 3 H), 2.11-2.18 (m, 2 H), 2.24 (t, J=7.93 Hz, 1 H), 3.16-3.21 (m, 2 H), 3.59-3.65 (m, 4 H), 6.54 (dd, J=3.05, 0.92 Hz, 1 H), 7.22-7.28 (m, 1 H), 7.32 (d, J=3.05 Hz, 1 H), 7.41-7.44 (m, 1 H), 7.60 (dd, J=8.54, 1.83 Hz, 1 H), 7.63-7.70 (m, 1 H), 8.10 ppm (d, J=1.83 Hz, 1 H); MS (ESI) m/z 310 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168791B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-d0a5102691c34cf1976680780cc3c8ce |
| Source note | uspto-grants-2012_05 |