3-Fluorobenzenesulfonyl Chloride → N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

HRID 192007Notes

Reaction equation

HRID 192007 reaction equation
[Cl:1][c:2]1[n:3][c:4](-[c:5]2[s:6][c:7]([CH:8]([CH3:9])[CH3:10])[n:11][c:12]2-[c:13]2[cH:14][c:15]([NH:16][S:17]([c:18]3[c:19]([F:20])[cH:21][cH:22][cH:23][c:24]3[F:25])(=[O:26])=[O:27])[cH:28][cH:29][cH:30]2)[cH:31][cH:32][n:33]1.[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39](-[c:41]2[c:42](-[c:49]3[cH:50][cH:51][c:52]([F:56])[c:53]([NH2:54])[cH:55]3)[n:43][c:44]([CH:46]([CH3:47])[CH3:48])[s:45]2)[n:40]1.[F:57][c:58]1[cH:59][c:60]([S:64](=[O:65])(=[O:66])[Cl:67])[cH:61][cH:62][cH:63]1>>[Cl:34][c:35]1[n:36][cH:37][cH:38][c:39](-[c:41]2[c:42](-[c:49]3[cH:50][cH:51][c:52]([F:56])[c:53]([NH:54][S:64]([c:60]4[cH:59][c:58]([F:57])[cH:63][cH:62][cH:61]4)(=[O:65])=[O:66])[cH:55]3)[n:43][c:44]([CH:46]([CH3:47])[CH3:48])[s:45]2)[n:40]1

Participants

4

Reactant 3

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroanilineHCID 57990030N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989802N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

Sources & evidence

ORD record
ord-47f6218d2b644330b9d5aef13e2bda63
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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