HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzamide → 4-bromo-N-(2,2-dichloro-1-hydroxybutyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzamide | HCID 69683 | — |
| Reactant | 2,2-Dichlorobutanal | HCID 11275051 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-bromo-N-(2,2-dichloro-1-hydroxybutyl)benzamide | HCID 58149553 | 51% |
Reaction Steps
4-Bromobenzamide 118 (1.0 g, 4.85 mmol), 2,2-dichlorobutanal (2 mL) and HCl (3 drops) in dioxane (4 mL) were heated to 120° C. (bath temperature) for 18 hours. The mixture was concentrated, and absorbed onto silica gel. Chromatography (CH2Cl2) produced an off-white solid as 4-bromo-N-(2,2-dichloro-1-hydroxybutyl)benzamide 119 (0.84 g, 51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168795B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-6facd840222d4cd5b72c0ce39c7c017e |
| Source note | uspto-grants-2012_05 |