Ethyl Bromide → HCID 86639861, compound

Participants

Reaction Conditions

Reaction Steps

While being maintained at 0° C., KOH (0.13 g, 2.4 mmol) was added to a solution of the (S)—N-{{3-[3,5-difluoro-4-(7-hydroxydimono?-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide (0.8 g, 1.4 mmol) obtained in Example 3 in 10 mL of DMF, and then slowly droplets of ethyl bromide (0.4 mL, 5.6 mmol) were added with stirring for 3 hours. After the reaction terminated, the reaction mixture was poured into cold water and extracted with ethyl acetate. The organic phase was washed with water and brine and dehydrated over anhydrous magnesium sulfate. Purification through flash column chromatography (n-hexane/ethyl acetate=1:4) afforded the target compound in a white pure form (0.52 g).

Provenance & Evidence