反应详情

温度

60 °C

To the compound (3.00 g) obtained in Example 9, 4N hydrogen chloride/dioxane (15 mL) was added. The reaction solution was stirred at 60° C. for 15 hours. The reaction solution was concentrated under reduced pressure. The residue was dissolved in methanol (20 mL) and a carbonate resin (trade name: MP-Carbonate, manufactured by Argonaut Co., product number: 800267, 10 g) was added, followed by stirring at room temperature for 3 hours. After the resin was removed by filtration, the filtrate was concentrated under reduced pressure. The title compound was obtained without purifying the residue.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. dissolutionThe residue was dissolved in methanol (20 mL)
3. additiona carbonate resin (trade name: MP-Carbonate, manufactured by Argonaut Co., product number: 800267, 10 g) was added
4. stirringby stirring at room temperature for 3 hours
5. customAfter the resin was removed by filtration
6. concentrationthe filtrate was concentrated under reduced pressure