Cyclohexanone, 4-(dipropylamino)- → N,N-bis({1-[(dimethylamino)sulfonyl]-1H-imidazol-2-yl}methyl)-2-[4-(dipropylamino)cyclohexyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide

Participants

Reaction Steps

The same operation as in Example 2 was performed, except for using the compound (150 mg) obtained in Example 31 and 4-(dipropylamino)cyclohexanone (269 mg), and then the obtained crude product was purified by silica gel chromatography (dichrolomethane:methanol:28% aqueous ammonia=1:0:0→80:10:1) to obtain the title compound (150 mg) having the following physical properties.

Provenance & Evidence