HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Thienylmethyl)-2,7-diazaspiro[4.4]nonane → N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Thienylmethyl)-2,7-diazaspiro[4.4]nonane | HCID 67500921 | — |
| Reactant | N-(4-formylbenzyl)-N-(1H-imidazol-2-ylmethyl)-1H-imidazole-2-carboxamide | HCID 86632126 | — |
| Product | N-(1H-imidazol-2-ylmethyl)-N-(4-{[7-(2-thienylmethyl)-2,7-diazaspiro[4.4]non-2-yl]methyl}benzyl)-1H-imidazole-2-carboxamide | HCID 57764679 | 54.4% |
Reaction Steps
The same operation as in Example 2 was performed, except for using the compound (107 mg) obtained in Example 38 in place of 2-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide, and 2-(2-thienylmethyl)-2,7-diazaspiro[4.4]nonane (86 mg) in place of benzylamine, to obtain the title compound (97 mg) having the following physical properties.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168783B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-29863d60b7e541c8a174c5fabb5f6872 |
| Source note | uspto-grants-2012_05 |