反应详情

To a solution of (S)-benzyl 3-(tert-butoxycarbonylamino)-5-ethylidenepiperidine-1-carboxylate (1 eq) in 5.5 mL of ethanol and 5.5 mL of EtOAc was added 10% Pd/C (0.1 eq). The resulting suspension was stirred at H2 atmosphere for 45 minutes. The crude solids were filtered through a pad of Celite on a paper lined Buchner funnel, washed with MeOH, then concentrated in vacuo. The residue was dissolved in 1.4 mL of isopropanol and DIPEA (2.5 eq) and 4-chloro-3-nitropyridine (1.5 eq) were added. The reaction mixture was stirred at 80° C. overnight, at which point the reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure. The residue was diluted with 120 mL of EtOAc, washed with brine, then dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The crude residue was purified by flash chromatography (EtOAc:hexanes=1:1) to yield tert-butyl(3S,5R)-5-ethyl-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate (91%). LC/MS (m/z): 351.2 (MH+), Rt: 0.75 min.

1. filtrationThe crude solids were filtered through a pad of Celite on a paper
2. washwashed with MeOH
3. concentrationconcentrated in vacuo
4. dissolutionThe residue was dissolved in 1.4 mL of isopropanol
5. stirringThe reaction mixture was stirred at 80° C. overnight, at which
6. concentrationconcentrated under reduced pressure
7. additionThe residue was diluted with 120 mL of EtOAc
8. washwashed with brine
9. dry with materialdried over anhydrous MgSO4
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customThe crude residue was purified by flash chromatography (EtOAc:hexanes=1:1)