HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate → Diethyl 4-chloropiperidin-3-ylphosphoramidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate | HCID 67500461 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Diethyl 4-chloropiperidin-3-ylphosphoramidate | HCID 67500859 | 92% |
Reaction Steps
To a solution of benzyl 4-chloro-3-(diethoxyphosphorylamino)piperidine-1-carboxylate (1.0 equiv.) in degassed MeOH was added Pd/C (10% by weight) and the reaction was stirred under a hydrogen atmosphere for 1 h. The solution was filtered, then concentrated to yield diethyl 4-chloropiperidin-3-ylphosphoramidate in 92% yield. LCMS (m/z): 271.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168794B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-dc1e5c611fa84bbc898b6f4165f34c32 |
| Source note | uspto-grants-2012_05 |