HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67500566, compound → Diethyl 1-(3-aminopyridin-4-yl)-4-chloropiperidin-3-ylphosphoramidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67500566 | HCID 67500566 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Diethyl 1-(3-aminopyridin-4-yl)-4-chloropiperidin-3-ylphosphoramidate | HCID 67500705 | 83% |
Reaction Steps
To a solution of diethyl 4-chloro-1-(3-nitropyridin-4-yl)piperidin-3-ylphosphoramidate (1.0 equiv.) in degassed EtOAc (0.1M) was added Pd/C (10% by weight) and the reaction was stirred under a hydrogen atmosphere for 18 h. Filtered and concentrated the filtrate to yield diethyl 1-(3-aminopyridin-4-yl)-4-chloropiperidin-3-ylphosphoramidate in 83% yield. LCMS (m/z): 363.1 (MH+), Rf=1.89 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168794B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8f6618330a914bfd808d42d1e7336065 |
| Source note | uspto-grants-2012_05 |