HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorobenzamide → 2,6-Difluorobenzene-1-carbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorobenzamide | HCID 87439 | — |
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,6-Difluorobenzene-1-carbothioamide | HCID 12683212 | 99% |
Reaction Steps
A solution of 2,6 difluorobenzamide (1 eq) and Lawesson's reagent (0.5 eq.) in toluene (0.2 M) was heated at 90° C. for 14 hours. Upon cooling the volatiles were removed in vacuo and purified by SiO2 chromatography (25% EtOAc/hexanes) yielding 2,6-difluorobenzothioamide as a light yellow solid (99%). LCMS (m/z): 174.1 (MH+); LC Rt=2.19 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168794B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-9ef41bd43a124cf385f9f7f3e6de0578 |
| Source note | uspto-grants-2012_05 |