HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2,6-Difluorobenzene-1-carbothioamide | HCID 12683212 | — |
| Reactant | Ethylbromopyruvate | HCID 21948992 | — |
| Product | Ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate | HCID 59455697 | 84% |
Reaction Steps
A solution of 2,6-difluorobenzothioamide (1.0 eq) and ethylbromopyruvate (1.0 eq.) in ethanol (1.0 M) was heated in the microwave at 130° C. for 30 minutes. Upon removal of volatiles in vacuo, ethyl acetate was added and the solution was washed with Na2CO3(sat.), with NaCl(sat.), was dried over MgSO4, filtered and concentrated yielding ethyl 2-(2,6-difluorophenyl)thiazole-4-carboxylate (84%). LCMS (m/z): 270.1 (MH+); LC Rt=3.79 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168794B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-5913f3fb4eb842b4b8f20c63978760a0 |
| Source note | uspto-grants-2012_05 |