Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| Solvent | Water | HCID 962 | — |
| Product | (-)-Carnitine | HCID 10917 | — |
Reaction Steps
Water (1777 g), aqueous sodium hydroxide (50%, 203.7 g, 1.5 eq.) and aqueous trimethylamine (25%, 807 g, 2.0 eq.) were mixed and stirred at 0° C. Ethyl (R)-4-chloro-3-hydroxybutyrate (content 91.7%, 307.9 g) was added dropwise during 3 h and the procedure was continued as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08168823B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-8340f31a4ccf40d4935e6bc4a67b3d58 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
