Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| Solvent | Water | HCID 962 | — |
| Product | (-)-Carnitine | HCID 10917 | — |
Reaction Steps
Sodium hydroxide (156.1 g, 3.9 mol, 1.4 eq) was dissolved in water (3700 g). Aqueous tri-methylamine (25%, 649.5 g, 1.0 eq) was added with cooling. The resulting mixture was cooled to 0° C. and ethyl (R)-4-chloro-3-hydroxybutyrate (content 91.5%, 500.0 g, 2.75 mol) was added dropwise within 3 h to the stirred reaction mixture. After one additional hour at 0° C. the reaction mixture was warmed to +20° C. and analyzed by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08168823B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-7d0a8d78a9ff43dcabfd74deaf3b232d |
|---|
| Source note | uspto-grants-2012_05 |
|---|
