Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)- | HCID 2734445 | — |
| Solvent | Water | HCID 962 | — |
| Product | (-)-Carnitine | HCID 10917 | — |
Reaction Steps
In a 250 mL reactor, ethyl (R)-4-chloro-3-hydroxybutyrate (content 94%, 12.00 g, 67.7 mmol) was stirred with water (75.04 g) and cooled to 0° C. Aqueous trimethylamine (25%, 17.71 g, 1.1 eq.) was added at once at 0° C., followed by dropwise addition of aqueous sodium hydroxide (25%, 15.30 g, 1.4 eq.) within 3 h. After another 1 h at 0° C. the reaction mixture was allowed to warm to 20° C. and analyzed by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08168823B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-c7c9a2cc172d43d1864f1bec9486c0b7 |
|---|
| Source note | uspto-grants-2012_05 |
|---|
