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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1920321Generated: October 29, 2026

Ethyl 4-(piperazin-1-yl)benzoate → 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-YL]methyl]-1-piperazinyl]benzoic acid ethyl ester

https://huagongshe.com/reaction/1920321

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-(piperazin-1-yl)benzoateHCID 2761178—
Reactant2-(4-chlorophenyl)-5,5-dimethyl-1-Cyclohexene-1-carboxaldehydeHCID 44594330—
Product4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-YL]methyl]-1-piperazinyl]benzoic acid ethyl esterHCID 25140483—

Reaction Steps

reacting 2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-ene-1-carbaldehyde, ethyl 4-piperazin-1-ylbenzoate and a first reducing agent and isolating or not isolating the ethyl 4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)benzoate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08168784B2
Source datasetuspto-grants-2012_05
ORD IDord-df143d6607974a4fbe01d368ec884f1b
Source noteuspto-grants-2012_05