HRID1920326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)CCC(=O)/C(=C/O[Si](C)(C)C(C)(C)C)C1

HCID44594327

未命名化合物

$结构：CC(C)[Si](O/C=C1\CC(C)(C)CCC1=O)(C(C)C)C(C)C$

HCID44594328

未命名化合物

HCID44594329

未命名化合物

HCID178478191

未命名化合物

PRODUCTS

生成物

结构：CC1(C)CCC(O)(c2ccc(Cl)cc2)/C(=C/O[Si](C)(C)C(C)(C)C)C1

HCID67079181

未命名化合物

$结构：CC(C)[Si](O/C=C1\CC(C)(C)CCC1(O)c1ccc(Cl)cc1)(C(C)C)C(C)C$

HCID67079716

未命名化合物

结构：CC1(C)CCC(O)(c2ccc(Cl)cc2)/C(=C/O[Si](C)(C)C)C1

HCID67079763

未命名化合物

PROCEDURE

实验过程

reacting the (2E)-4,4-dimethyl-2-(((triisopropylsilyl)oxy)methylene)cyclohexanone, (2E)-4,4-dimethyl-2-(((trimethylsilyl)oxy)methylene)cyclohexanone, or (2E)-2-(((tert-butyl(dimethyl)silyl)oxy)methylene)-4,4-dimethylcyclohexanone and 4-chlorophenyl magnesium bromide to provide ((2E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(((triisopropylsilyl)oxy)methylene)cyclohexanol, (2E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(((trimethylsilyl)oxy)methylene)cyclohexanol, or (2E)-2-(((tert-butyl(dimethyl)silyl)oxy)methylene)-1-(4-chlorophenyl)-4,4-dimethylcyclohexanol; and isolating or not isolating the (2E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(((triisopropylsilyl)oxy)methylene)cyclohexanol, (2E)-1-(4-chlorophenyl)-4,4-dimethyl-2-(((trimethylsilyl)oxy)methylene)cyclohexanol, or (2E)-2-(((tert-butyl(dimethyl)silyl)oxy)methylene)-1-(4-chlorophenyl)-4,4-dimethylcyclohexanol; and

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf86d740f93844d39454f8e2902a6e29
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08168784B2
来源说明: uspto-grants-2012_05

反应 SMILES

[CH3:1][C:2]1([CH3:21])[CH2:7][CH2:6][C:5](=[O:8])/[C:4](=[CH:9]/[O:10][Si:11]([CH:18]([CH3:20])[CH3:19])([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])/[CH2:3]1.[CH3:22][C:23]1([CH3:36])[CH2:28][CH2:27][C:26](=[O:29])/[C:25](=[CH:30]/[O:31][Si:32]([CH3:35])([CH3:34])[CH3:33])/[CH2:24]1.[Si:37]([O:44]/[CH:45]=[C:46]1/[C:47](=[O:54])[CH2:48][CH2:49][C:50]([CH3:53])([CH3:52])[CH2:51]/1)([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38].[Cl:55][C:56]1[CH:61]=[CH:60][C:59]([Mg]Br)=[CH:58][CH:57]=1>>[Cl:55][C:56]1[CH:61]=[CH:60][C:59]([C:5]2([OH:8])[CH2:6][CH2:7][C:2]([CH3:1])([CH3:21])[CH2:3]/[C:4]/2=[CH:9]\[O:10][Si:11]([CH:15]([CH3:17])[CH3:16])([CH:12]([CH3:14])[CH3:13])[CH:18]([CH3:20])[CH3:19])=[CH:58][CH:57]=1.[Cl:55][C:56]1[CH:61]=[CH:60][C:59]([C:26]2([OH:29])[CH2:27][CH2:28][C:23]([CH3:36])([CH3:22])[CH2:24]/[C:25]/2=[CH:30]\[O:31][Si:32]([CH3:34])([CH3:33])[CH3:35])=[CH:58][CH:57]=1.[Si:37]([O:44]/[CH:45]=[C:46]1/[C:47]([C:59]2[CH:60]=[CH:61][C:56]([Cl:55])=[CH:57][CH:58]=2)([OH:54])[CH2:48][CH2:49][C:50]([CH3:53])([CH3:52])[CH2:51]/1)([C:40]([CH3:43])([CH3:42])[CH3:41])([CH3:39])[CH3:38]