(Trifluoromethyl)trimethylsilane → 1-Fluoro-2-(trifluoromethylsulfonyl)benzene

HRID 1920400Notes

Reaction equation

HRID 1920400 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8](F)(=[O:10])=[O:9].C[Si]([C:16]([F:19])([F:18])[F:17])(C)C>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([C:16]([F:19])([F:18])[F:17])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 141952602-Fluorobenzene-1-sulfonyl fluoride

Product 1

HCID 157316611-Fluoro-2-(trifluoromethylsulfonyl)benzene

Procedure

reacting the 2-fluorobenzenesulfonyl fluoride, Ruppert's reagent (CH3SiCF3), and tris(dimethylamino)sulfonium difluorotrimethylsilicate at about room temperature to provide 1-fluoro-2-((trifluoromethyl)sulfonyl)benzene and isolating or not isolating the 1-fluoro-2-((trifluoromethyl)sulfonyl)benzene;

Workup

  1. customat about room temperature

Sources & evidence

ORD record
ord-26f6dcd3b4f9462d88bc43ebe4923a46
Source dataset
uspto-grants-2012_05
Patent number
US08168784B2

Reaction notes

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