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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1920402Generated: October 28, 2026

Ammonium Hydroxide → 4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

https://huagongshe.com/reaction/1920402

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmonium HydroxideHCID 14923—
Reactant4-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl chlorideHCID 56972867—
Product4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamideHCID 25058452—

Reaction Steps

reacting 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonyl chloride, and aqueous ammonium hydroxide at about −5° C. to about −60° C. to provide 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide and isolating or not isolating the 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide; and

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08168784B2
Source datasetuspto-grants-2012_05
ORD IDord-e5d50693ab4f472298f3678d352819f1
Source noteuspto-grants-2012_05