反应详情

A solution of [(4R,6S)-2,2-dimethyl-6-(3-nitro-pyrazol-1-ylmethyl)-[1,3]dioxan-4-yl]-acetic acid t-butyl ester (1.56 g 3.52 mmol) in ethanol (25 mL) was hydrogenated in a Parr hydrogenator at 50 psi hydrogen pressure, using 10% palladium on carbon (0.2 g, 0.19 mmol), for 3 h. The reaction mixture was filtered through a celite plug, and the filtrate concentrated which afforded [(4R,6S)-6-(3-amino-pyrazol-1-ylmethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-acetic acid t-butyl ester (1.34 g, 94%) as a yellow solid.

1. filtrationThe reaction mixture was filtered through a celite plug
2. concentrationthe filtrate concentrated which