HRID1920556

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID564919

Phenyl bromoacetate

C8H7BrO2

结构：O=C(C[N+]12CCC(CC1)[C@@H](OC(=O)C(F)(c1ccccc1)c1ccccc1)C2)Oc1ccccc1.[Br-]

HCID86611363

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCC[N+]12CCC(CC1)[C@@H](OC(=O)C(F)(c1ccccc1)c1ccccc1)C2.[Br-]

HCID67496806

未命名化合物

结构：C#CC[N+]12CCC(CC1)[C@@H](OC(=O)C(F)(c1ccccc1)c1ccccc1)C2.[Br-]

HCID86611365

未命名化合物

PROCEDURE

实验过程

These compounds, namely (R)-3-(2-Fluoro-2,2-diphenyl-acetoxy)-1-prop-2-ynyl-1-azonia-bicyclo[2.2.2]octane bromide and (R)-1-(2-Acetoxy-ethyl)-3-(2-fluoro-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide are prepared by an analogous method to (R)-3-(2-fluoro-2,2-diphenyl-acetoxy)-1-phenoxycarbonylmethyl-1-azonia-bicyclo[2.2.2]octane bromide (Example 109) by replacing bromo-acetic acid phenyl ester with the appropriate alkyl halide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6c483e0201404b9c8ceb98953317125d
来源数据集: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08168654B2
来源说明: uspto-grants-2012_05

反应 SMILES

[Br-:1].[F:2][C:3]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:4]([O:6][C@@H:7]1[CH:12]2[CH2:13][CH2:14][N+:9]([CH2:15][C:16](OC3C=CC=CC=3)=[O:17])([CH2:10][CH2:11]2)[CH2:8]1)=[O:5].[C:37]1([O:43]C(=O)C[Br:46])C=CC=C[CH:38]=1>>[Br-:46].[F:2][C:3]([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)([C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1)[C:4]([O:6][C@@H:7]1[CH:12]2[CH2:13][CH2:14][N+:9]([CH2:15][C:16]#[CH:37])([CH2:10][CH2:11]2)[CH2:8]1)=[O:5].[Br-:1].[C:37]([O:17][CH2:16][CH2:15][N+:9]12[CH2:10][CH2:11][CH:12]([CH2:13][CH2:14]1)[C@@H:7]([O:6][C:4](=[O:5])[C:3]([F:2])([C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[CH2:8]2)(=[O:43])[CH3:38]