HCID 67496128, compound → HCID 131729693, compound

HRID 1920561Notes

Reaction equation

HRID 1920561 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[C:8](NCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(C1C=CC=CC=1)C1C=CC=CC=1)C2)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl.[Cl-].[NH2:47][CH:48]([CH3:75])[CH2:49][N+:50]12[CH2:57][CH2:56][CH:53]([CH2:54][CH2:55]1)[C@@H:52]([O:58][C:59](=[O:74])[C:60]([OH:73])([C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)[C:61]1[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1)[CH2:51]2>>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[C:8]([NH:47][CH:48]([CH3:75])[CH2:49][N+:50]12[CH2:57][CH2:56][CH:53]([CH2:54][CH2:55]1)[C@@H:52]([O:58][C:59](=[O:74])[C:60]([OH:73])([C:61]1[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=1)[C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)[CH2:51]2)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 67496128HCID 67496128, compoundHCID 67496503HCID 67496503, compound

Product 1

HCID 131729693HCID 131729693, compound

Procedure

This compound is prepared analogously to (R)-1-(3-benzoylamino-propyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]-octane trifluoroacetate [Example 2] but by replacing (R)-1-(3-amino-propyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo-[2.2.2]octane chloride hydrochloride [Example 1(ii)] with (R)-1-((R/S)-2-amino-propyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azoniabicyclo[2.2.2]octane chloride hydrochloride.

Sources & evidence

ORD record
ord-824a81d27e934e86b55b2ac5f274f8fb
Source dataset
uspto-grants-2012_05
Patent number
US08168654B2

Reaction notes

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