HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Benzyloxy)benzoic acid → HCID 67496802, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Benzyloxy)benzoic acid | HCID 73880 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67496660 | HCID 67496660 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67496802 | HCID 67496802 | — |
Reaction Steps
To a solution of 4-benzyloxybenzoic acid (0.126 mg, 0.55 mmol) in DMF (3 ml) is added diisopropylethylamine (0.3 ml) followed by HATU (0.155 mg, 0.55 mmol). The reaction mixture is stirred for 30 minutes at room temperature after which time a solution comprising (R)-1-(2-amino-ethyl)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane bromide hydrobromide [Example 49(ii)] (0.200 g, 0.37 mmol) and the resulting mixture is stirred at room temperature over night. Purification is carried out using preparative C18 column chromatography eluting with acetonitrile: water to afford the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168654B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-67b9ccf1880b40fcae2820165331eed5 |
| Source note | uspto-grants-2012_05 |